A study of 130,828 adults (average age, 55.7 years; 61% women) with insomnia found that prolonged melatonin use is linked to an 89% higher risk of heart failure and increased hospitalization and mortality rates. Conducted using the TriNetX Global Research Network database, the study compared melatonin users to non-users over five years. The findings challenge previous beliefs about the safety of melatonin, highlighting the need for further research into its cardiovascular effects.
The Takeaway: Long-term melatonin use may increase risk for heart failure, urging caution.
Cited from Medscape